Shopping Cart
Your Cart is Empty
Quantity:
Subtotal
Taxes
Shipping
Total
There was an error with PayPalClick here to try again
CelebrateThank you for your business!You should be receiving an order confirmation from Paypal shortly.Exit Shopping Cart

Agape Healing Arts

Health & Wellness Center

385 Tequesta Drive Ste. 4 Tequesta FL 33469 ~ Office 561-762-4273

Blog

Blog

C-reactive protein (CRP)

Posted on May 28, 2020 at 11:20 PM


C-reactive protein (CRP)

 


The condition is low-grade inflammation, which may originate in a variety of unlikely places throughout the body, including even excess fat. New federal recommendations are being written that will urge doctors to test millions of middle-aged Americans for it.

The discovery of its surprising ill effects is causing a top-to-bottom rethinking of the origins and prevention of heart trouble. Doctors call it a revolutionary departure from viewing the world's top killer as largely a plumbing problem blamed on cholesterol-clogged arteries, the standard theory through the modern era of cardiology.

"The implications of this are enormous," says Dr. Paul Ridker of Boston's Brigham and Women's Hospital. "It means we have an entire other way of treating, targeting and preventing heart disease that was essentially missed because of our focus solely on cholesterol."


Testing Healthy People

In the past year or two, experts say, the evidence has become overwhelming that inflammation hidden deep in the body is a common trigger of heart attacks, even when clogging in the arteries is minimal. Now the main question is: How aggressively should otherwise healthy people be tested to find and treat it?

The new recommendations are still being drawn up, but they will offer the first formal blueprint to answer this, probably sometime in the fall. Doctors writing them say they will almost certainly recommend broad testing.

 

Inflammation can be measured with a generic $10 test that looks for high levels of a chemical called C-reactive protein, one of many that increase during inflammation. Experts expect it to quickly become a standard part of physical exams. As a result, many people ordinarily consid- ered at low risk will probably be put on statin drugs, which lower inflammation as well as cholesterol.

 

No one disputes the importance of cholesterol. Yet half of all heart attack victims have levels that are normal or even low. Clearly, something big was missing from the equation, and that appears to be inflammation.

 

Ridker estimates that between 25 million and 35 million healthy middle-aged Americans have normal cholesterol but above-average inflammation, putting them at unusual risk of heart attacks and strokes.

 

A series of landmark studies by his team, beginning in 1997, suggest inflammation is more important than cholesterol at triggering heart attacks. They found those with high levels of C-reactive protein have twice the risk of people with elevated cholesterol.

 

High amounts of the protein also predict increased risk of heart attacks and strokes years before they occur, even when cholesterol levels are low. Having both inflammation and high cholesterol together is especially ominous, resulting in a nine-fold increase in risk.

 

Everyone who reaches middle age has some degree of fatty buildup, called plaque, in the heart arteries. The new evidence suggests it becomes threatening if weakened by inflammation, which makes it squishy and fragile. Even a small lump of plaque can burst like an overripe pimple, prompting the formation of a clot that in turn chokes off blood flow and causes a heart attack.

 

Many people with no outward signs of anything wrong have high levels of internal inflammation. It is exactly the same sort that causes swelling, heat and redness during infections or allergic rashes.

 

Doctors believe the internal inflammation has many possible sources. Often, the plaque itself becomes inflamed as white blood cells invade in a misguided defense attempt. But inflammation that arises elsewhere apparently can be as bad, for it bombards the plaque with damaging chemicals.

 

For instance, fat cells churn out these inflammatory proteins, which helps explain why being overweight is so bad for the heart. Other possible triggers include high blood pressure, smoking and lingering low-level infections, such as chronic gum disease.

 

Although many chemicals increase during inflammation, C-reactive protein, or CRP, is particularly easy to measure. Some already test for it, including White House doctors, who checked President Bush's CRP level last summer. (His was extremely low.)


CRP Recommendations

In March, the Centers for Disease Control and Prevention and the American Heart Association held a meeting of 50 experts in Atlanta to review the scientific evidence on inflammation and make recommendations.

These are still being discussed, but some doctors involved say they are likely to urge CRP screening for people already considered at mild to moderate risk of heart attacks. These include smokers and those with a combination of other less ominous risks, such as being middle-aged and having borderline high cholesterol or blood pressure. For instance, they might recommend

 

CRP testing for a 45-year-old man with cholesterol in the low 200s and blood pressure just be- low the cutoff for treatment.  However, others believe CRP should measured in everyone over age 40, just like cholesterol, regardless of their other risk factors.  "It begins to look like a standard risk factor that one would evaluate at least once in middle age in most people," says Dr. Wayne Alexander of Emory University, one member of the recom- mendations committee. "This is a very important concept for the general public to be aware of and to think about for their own health."

Doctors hope to have the recommendations ready for publication in the journal Circulation in November, followed by a campaign to teach doctors and ordinary people about it. "Our goal is to have a broad-based consensus and use all available means to disseminate that information widely," says Dr. George Mensah, the CDC's chief of cardiovascular health.  Many hospitals can already do the test. However, until the recommendations come out, most doctors are unlikely to know exactly whom to test or what to make of the results. In fact, the White House doctors who checked Bush had to call Ridker to figure out how to interpret his numbers.


The Effects of CRP Screening

CRP probably will not matter much for heart attack survivors and others who already know they have heart disease, since presumably doctors are already doing everything they can to keep their condition from getting worse.

"We believe the niche for C-reactive protein - and it is a large niche - is the healthy population who want to do what they can to lower their risk of cardiovascular disease," says Dr. Richard Cannon of the National Heart, Lung and Blood Institute.

Screening is important because inflammation can be readily lowered in several ways. One of the most powerful is losing weight. Exercise also helps, as does moderate alcohol intake, giving up smoking and lowering blood pressure.

Of course, this amounts to the same healthy living advice that doctors have long dispensed. But now they have a much better understanding of why it works so well. Furthermore, they are likely to urge these habits on people with bad CRP readings who until now would have seemed to be at no special risk of heart problems.

 

Many of the standard heart medicines also lower inflammation. These include aspirin, Plavix, ACE inhibitors and the statin drugs, such as Lipitor and Zocor. The statins are now prescribed to lower cholesterol, and they do so dramatically. But studies have shown they ward off heart attacks much more powerfully than would be expected from their effects on cholesterol alone. In fact, people with moderate cholesterol seem to benefit just like those with readings off the charts. Lowering inflammation probably explains why.

Still, some important details remain to be settled. One is population-wide data on CRP levels and their connection to heart disease. Ridker is finishing a large study, to be released later this year, that traces this relationship with CRP readings from tens of thousands of people.

"Paul has got data now that slam-dunks it," says Dr. Richard Milani of the Ochsner Clinic in New Orleans.

Another gap is rock-solid evidence that lowering inflammation truly prevents heart attacks and saves lives. Ridker hopes to prove this with a study to begin this fall that will compare statin drugs and dummy pills in 15,000 middle-aged men and women with normal cholesterol and above average CRP.

The new thinking about inflammation "will change everything we do in heart disease," predicts Dr. Eric Topol, cardiology chief at the Cleveland Clinic.

"In the last decade, people talked about their cholesterol levels," he says. "In the next decade, the cocktail chatter will be, 'What's your C-reactive protein?' Everyone will need to know that."

Categories: None

Post a Comment

Oops!

Oops, you forgot something.

Oops!

The words you entered did not match the given text. Please try again.

2136 Comments

Reply catiewithac
7:56 PM on August 10, 2022 
nike tampa bay buccaneers 22 doug martin 2013 drift fashion red kids jersey 2014 new nfl jerseys minnesota vikings 28 adrian peterson black gold no fashion elite jerseys men nike tennessee titans 61 fernando velasco limited navy blue alternate nfl jersey sale pandora nan necklace
catiewithac http://www.catiewithac.com/
Reply cheap steph curry shoes
6:06 PM on August 10, 2022 
I needed to send you a very little word just to say thanks over again about the awesome basics you have contributed in this case. It has been simply wonderfully open-handed with people like you to make without restraint what a number of people would've offered for an electronic book to get some bucks on their own, especially seeing that you could have done it in case you considered necessary. Those strategies likewise worked like the great way to be sure that many people have a similar interest similar to my personal own to know the truth lots more with reference to this problem. I am sure there are thousands of more pleasurable periods in the future for people who view your site.
cheap steph curry shoes http://www.stephcurryshoes.com
Reply Paullat
4:58 PM on August 10, 2022 
metformin 25 mg
Reply ArthurPep
4:52 PM on August 10, 2022 
Instant Loans BIRD is not just a loan agency. We are a team of financial experts that is aimed to help borrowers realize their bold financial dreams and cover daily expenses. We do everything possible to change the lending market for the better by creating affordable financial services, including small loans with no credit check, bad credit personal loans, and cash advances with instant money deposit. We’re proud to be your #1 direct loans lender when it comes to the quick loans available to everyone.

https://ilbird.net/our-stores/
https://ilbird.net/store-in-union-city-new-jersey/
Reply tobiconnors
3:37 PM on August 10, 2022 
buffalo plaid beanie with pom celtic fc tracksuit bottoms raglan sleeve tie front flare satin dress north face kilowatt jacket polo ralph lauren jeans sale moncler winter coat
tobiconnors http://www.tobiconnors.com/
Reply golden goose
3:35 PM on August 10, 2022 
I want to convey my passion for your kind-heartedness for folks who really need help with this particular concern. Your very own commitment to passing the solution around appeared to be wonderfully advantageous and have in every case helped folks like me to reach their dreams. Your entire interesting tutorial indicates a lot to me and far more to my office colleagues. Regards; from each one of us.
golden goose http://www.goldengooseofficial.com
Reply supreme hoodie
2:27 PM on August 10, 2022 
I in addition to my friends were analyzing the nice guides found on the blog then suddenly got a horrible suspicion I had not thanked the blog owner for those tips. My women are actually consequently excited to learn all of them and have in effect actually been tapping into these things. We appreciate you turning out to be really accommodating and also for using this form of decent topics most people are really desperate to be aware of. My honest regret for not saying thanks to earlier.
supreme hoodie http://www.supremes-clothing.com
Reply kobe shoes
1:57 PM on August 10, 2022 
I wanted to create you this very small observation in order to thank you so much the moment again for the unique pointers you have featured here. It was shockingly open-handed of people like you to grant easily all that many people would have sold for an e-book to get some bucks for their own end, particularly given that you could possibly have tried it if you ever decided. The good tips additionally served to provide a good way to comprehend other individuals have similar eagerness similar to my very own to realize lots more when it comes to this condition. I'm certain there are thousands of more fun opportunities in the future for individuals who see your site.
kobe shoes http://www.kobe.us.com
Reply jordan shoes
12:22 PM on August 10, 2022 
Needed to send you the little word to be able to say thanks a lot once again for your stunning knowledge you have provided on this website. It is simply extremely open-handed with people like you in giving without restraint all many people would have offered as an ebook to get some cash on their own, precisely given that you could possibly have tried it in case you desired. The things as well served to become a good way to recognize that the rest have the same dream like my very own to learn great deal more with reference to this issue. Certainly there are a lot more pleasant moments up front for many who browse through your blog.
jordan shoes http://www.jordan4.us.com
Reply RaymondJef
12:00 PM on August 10, 2022 
????? ???? ???? https://seksipopa.com/ ????? ???????? ?????? ? ??????? ????? ????

[IMAGE]

????? ???? ????????
????? ???? ???
????? ??????? ?? ????
?????????? ???? ?????
????? ???? ??????
???????? ????? ????
????? ???? ? ???????
????? ???? ?????????
????? ???? ????
????? ????? ??????? ? ???? ????????
ed5e36_
Reply cheap kyries
10:05 AM on August 10, 2022 
A lot of thanks for your entire hard work on this website. Debby delights in carrying out research and it's obvious why. Most people know all of the dynamic tactic you provide invaluable tactics on this web blog and in addition encourage response from other ones on that subject and our child is always being taught a lot of things. Enjoy the rest of the year. You're conducting a first class job.
cheap kyries http://www.kyrieirvingshoes.us.com
Reply MichaelBic
7:02 AM on August 10, 2022 
how much is gabapentin 100mg
Reply Jorvom
5:50 AM on August 10, 2022 
?????? ?????? ?????? ?? ?????? ????? ??? ????? ???????? «????????? ????????»

https://yourdesires.ru/psychology/psychology-of-relationships/109
-strah-skazat-net.html
Reply air jordan
5:43 AM on August 10, 2022 
I precisely wished to appreciate you again. I am not sure what I could possibly have made to happen in the absence of the entire tips and hints provided by you regarding that topic. Completely was a real intimidating dilemma for me personally, however , taking a look at a new specialised manner you processed that forced me to jump with gladness. I will be happier for this information and wish you comprehend what an amazing job you happen to be getting into educating people by way of your webpage. Most probably you have never met any of us.
air jordan http://www.jordan1shoes.us
Reply BlakeNor
12:39 AM on August 10, 2022 
?????????? ???? ????? 21 https://porno-kino.top/ ???? ????? ????? ??????? ???????

[IMAGE]

????? ???? ????? ???????
???? ?????? ???????? ????????? ????? ??????
???? ????? ???? ????? ??????? ?????????
????? ???? ??????? ???????
???? ?????? 2020 ?????
????? ????????????? ????
????? ???? ?? ??????? 2020
????? ????? ?????? ????
????? ????? ???? ?????? ????????? ????????
???? ?????? ?????
7dc4982
Reply PercyDem
11:02 PM on August 9, 2022 
???? ??????? ???? https://seksfotka.top/ ??????? ? ????? ??????

[IMAGE]

???? ???? ??????? ?????
???? ???? ???
???? ????? ???? ????
????? ??????? ????? ???????
????? ???? ?????????? ????
???? ????? ??????? ? ??????? ?????
????? ??????? ????????? ??? ???????????
???? ???? ??????? ???????
???????? ?????????? ????? ???????
???? ???? ????? ????
d954bca
Reply yeezy
9:32 PM on August 9, 2022 
I'm just writing to let you understand of the beneficial experience my cousin's child went through visiting your webblog. She noticed numerous issues, which included what it's like to possess a marvelous coaching mood to make men and women easily gain knowledge of a variety of specialized subject areas. You actually surpassed our desires. Many thanks for offering the invaluable, healthy, explanatory and even cool tips about your topic to Mary.
yeezy http://www.yeezysshoes.us
Reply moncler outlet
9:31 PM on August 9, 2022 
I must express my respect for your kindness supporting those who really need help with in this subject. Your special dedication to passing the solution across had become extraordinarily practical and have consistently made individuals like me to realize their pursuits. Your entire invaluable tips and hints implies this much to me and even more to my mates. Thank you; from each one of us.
moncler outlet http://www.monclercoat.us.com
Reply kyrie irving shoes
9:30 PM on August 9, 2022 
A lot of thanks for every one of your labor on this web page. My daughter delights in engaging in investigation and it's really simple to grasp why. Most of us hear all regarding the compelling way you create important tips through this website and as well as foster response from other ones on this area of interest plus our own princess is studying a lot. Take advantage of the rest of the new year. You are always carrying out a really great job.
kyrie irving shoes http://www.kyrieirvingshoes.us.com
Reply kyrie 5
9:30 PM on August 9, 2022 
I want to show my passion for your generosity for men and women that must have help on that study. Your personal dedication to getting the solution throughout ended up being really helpful and have in most cases allowed guys and women just like me to attain their ambitions. Your insightful tips and hints means a great deal a person like me and substantially more to my colleagues. Warm regards; from each one of us.
kyrie 5 http://www.kyrie5.org