Shopping Cart
Your Cart is Empty
Quantity:
Subtotal
Taxes
Shipping
Total
There was an error with PayPalClick here to try again
CelebrateThank you for your business!You should be receiving an order confirmation from Paypal shortly.Exit Shopping Cart

Agape Healing Arts

Health & Wellness Center

385 Tequesta Drive Ste. 4 Tequesta FL 33469 ~ Office 561-762-4273

Blog

Blog

Can Angiogenesis Detect Early Breast Cancer?

Posted on May 28, 2020 at 10:15 PM


Can Angiogenesis Detect Early Breast Cancer?

 

While the prognostic significance of tumor angiogenesis remains a topic of intense interest and study, a California radiologist is waging a

largely unnoticed campaign to promote neovascularity as a diagnostic marker for early stage breast cancer.

Dr. Parvis Gamagami

Certain types of vascular formations often precede the appearance of breast tumors on mammography, sometimes by more than a decade,

said Parvis Gamagami, M.D., a radiologist at the Breast Center in Van Nuys, Calif.

Specifically, he cited hypervascularity, enlarged or engorged arteries, and calcified arteries as vascular markers that he and colleagues at

the center have used to identify breast cancers smaller than 5 mm. Of these, the best marker is calcification in the artery, Gamagami said.

At the San Antonio Breast Cancer Symposium in December, Gamagami reported findings from a retrospective review of mammograms

made up to 13 years before breast cancer diagnosis. Among 204 patients, cancer- associated angiogenesis preceded more than 90% of

nonpalpable tumors and 100% of the palpable lesions.

 

Gamagami's report represented the first major attempt at public discussion of angiogenesis' diagnostic potential in breast cancer. Gama-

gami and his colleagues will publish their first paper on the subject later this year in the Breast Journal. The radiologist has also begun

 

work on a text that will review evidence collected over the past 15 years.

Authorities on tumor angiogenesis and breast cancer diagnosis say they are unaware of any other reports on the diagnostic potential of

neovascularity.

By Gamagami's admission, the San Antonio presentation swayed few if any opinions. "If you don't have experience with something," he

said, "you don't know what questions to ask."

 

On the basis of laboratory and clinical observations, the Van Nuys group believes that mammographically detectable breast cancer angio-

genesis evolves in two stages: Preneoplastic cells secrete angiogenic factors that stimulate dormant blood vessels, which increase in num-

ber and size, and then a malignant lesion forms its own nutrient and drainage vessels. Over the course of time, contiguous calcifications

 

that envelop the nutrient artery help distinguish the vessel from the drainage vein on mammography.

Before It's Visible

 

"Our work has demonstrated that these neovascular formations appear on mammography before the tumor is even visible," said Gama-

gami, although most physicians, he believes, overlook the formations or dismiss them as normal asymmetry. "What you don't know

 

about, you don't look for."

Neovascularity may have played a role in the rise and fall of thermography's potential as a breast cancer diagnostic tool. The California

 

group has found evidence that tumor angiogenesis causes mammographic "hot spots" in the affected breast even in the absence of recog-

nized signs of developing cancer. The investigators have begun a clinical evaluation of the feasibility of performing thermography-guided

 

biopsies.

 

"Thermography was eliminated from the diagnostic arsenal because the findings did not correlate with clinical findings, physical exami-

nation, and mammography," said Gamagami. "Everyone concluded that thermography had a high rate of false-positives. Now we know

 

the reason for those false-positive findings: angiogenesis."

 

Outside the Van Nuys clinic, other cancer specialists remain skeptical about the diagnostic potential of angiogenesis. San Antonio radi-

ologist Pam Otto, M.D., who saw the poster at the breast cancer symposium, questions the sensitivity and specificity of the approach.

 

"If you're talking about arterial circulation, that's microscopic and I think it will be very hard to see on mammography," said Otto, an as-

sistant professor of radiology at the University of Texas Health Science Center in San Antonio.

 

Houston breast imaging specialist Carol Stelling, M.D., is unfamiliar with the work but questions its diagnostic value.

"To take out a [mammographically] busy breast and pick out a vascular pattern seems a little pie in the sky to me," said Stelling, head of

breast imaging at the University of Texas M. D. Anderson Cancer Center in Houston. "I'm not saying that it's not possible, but how we

position the breast and other factors can affect the view.

"Theoretically, we're looking at cellular changes and very small foci," Stelling continued. "For that to be reflected in a major change in an

artery at a very early time frame seems unlikely. In theory, it doesn't seem like it would be necessary for the blood supply to change with

the earliest, very small tumors."

Dr. Judah Folkman

Tumor angiogenesis authority Judah Folkman, M.D., of Harvard University, Boston, also is unaware of any reported findings involving

the diagnostic potential of angiogenesis, but he would welcome such a development.

 

"If they have indeed found something, that would be neat because I don't know of anyone else who has done that," said Folk-

man, the Julia Dyckman Andrus Professor of Pediatric Surgery. "We keep a running literature search of the whole field [of an-

giogenesis], and I don't recall having seen anything on diagnosis."

 

He adds that the group will likely face a questioning, skeptical oncology community until the investigators have a large, pro-

spective patient series to validate their findings.

 

"If they have only one abstract and no formal papers with statistical validation, I would suspect that the work will really be at-

tacked," he said. "That doesn't mean it's not true, but people tend to be really skeptical because there is such a big potential for

 

false-positive findings."

Gamagami and colleagues are no strangers to skepticism. "But before people decide this is right or wrong, I would just ask that

they look at what we have done and talk to someone who has been working in this area for 15 years," said Gamagami.

"Eighty percent of the breast cancer patients who come to us already have a palpable mass," he explained. "Only 20% have a

nonpalpable mass. If we could have an effect on the 80%, then we could have a real impact on breast cancer mortality."

-- Charles Bankhead

Categories: None

Post a Comment

Oops!

Oops, you forgot something.

Oops!

The words you entered did not match the given text. Please try again.

2025 Comments

Reply bape
4:12 PM on August 10, 2022 
I'm just writing to let you be aware of of the terrific experience my cousin's child went through visiting your site. She came to understand lots of issues, most notably how it is like to possess an incredible coaching nature to let the others just gain knowledge of several very confusing issues. You truly did more than readers' expected results. Thanks for giving the priceless, dependable, explanatory and in addition easy tips about your topic to Ethel.
bape http://www.bapehoodie.us
Reply supreme sweatshirt
4:12 PM on August 10, 2022 
I and also my friends have already been going through the excellent secrets and techniques on your web page and then unexpectedly came up with a horrible feeling I never expressed respect to the web site owner for those techniques. All the guys were definitely so glad to read all of them and already have definitely been enjoying them. Thank you for actually being very thoughtful and then for figuring out some important ideas most people are really eager to learn about. My honest regret for not expressing gratitude to you earlier.
supreme sweatshirt http://www.supremeshirt.us.com
Reply a bathing ape
4:10 PM on August 10, 2022 
Thanks so much for giving everyone a very memorable possiblity to discover important secrets from this blog. It is often very fantastic plus full of a lot of fun for me and my office colleagues to visit your website at minimum 3 times in 7 days to read through the fresh secrets you have got. And of course, I'm just actually motivated for the staggering solutions you give. Certain 2 points on this page are surely the very best we have all ever had.
a bathing ape http://www.bapes.us.org
Reply off white
2:56 PM on August 10, 2022 
Thank you for your entire work on this blog. Betty really loves working on investigation and it's simple to grasp why. A lot of people notice all concerning the compelling method you convey worthwhile tips and tricks through the website and as well as encourage response from some others on this topic plus our favorite daughter is undoubtedly understanding a whole lot. Have fun with the remaining portion of the year. You're the one performing a fabulous job.
off white http://www.offwhiteoutlet.us.org
Reply off white t shirt
12:29 PM on August 10, 2022 
I precisely desired to thank you so much once again. I do not know the things that I might have used in the absence of those solutions documented by you directly on such a area of interest. Previously it was a frightening problem in my opinion, but taking note of the very professional technique you solved that forced me to cry for contentment. I'm just happy for the guidance and wish you find out what an amazing job that you're getting into teaching men and women all through a web site. More than likely you've never got to know any of us.
off white t shirt https://www.offwhitesoutlet.com
Reply moncler
12:28 PM on August 10, 2022 
I actually wanted to construct a small message to appreciate you for all of the remarkable points you are posting on this site. My incredibly long internet search has at the end been paid with good concept to write about with my guests. I would believe that we site visitors are definitely blessed to be in a wonderful site with so many awesome individuals with interesting pointers. I feel somewhat privileged to have encountered the website and look forward to plenty of more entertaining times reading here. Thank you again for a lot of things.
moncler http://www.moncler--outlet.us.com
Reply goyard bags
12:26 PM on August 10, 2022 
I enjoy you because of your entire efforts on this web page. Kate enjoys working on investigations and it's obvious why. All of us learn all of the lively form you make useful thoughts by means of this blog and in addition cause contribution from the others about this content then our favorite girl is actually studying a great deal. Enjoy the remaining portion of the new year. You have been conducting a pretty cool job.
goyard bags http://www.goyardshandbag.com
Reply cheap curry 6
9:26 AM on August 10, 2022 
I must convey my appreciation for your generosity giving support to all those that must have assistance with the subject matter. Your special commitment to passing the message all through turned out to be definitely useful and has usually helped somebody much like me to reach their aims. The warm and friendly publication can mean much a person like me and further more to my office colleagues. With thanks; from everyone of us.
cheap curry 6 http://www.curry-6.us
Reply supreme clothing
9:26 AM on August 10, 2022 
My husband and i felt really more than happy when Chris could deal with his preliminary research through your ideas he acquired in your web pages. It is now and again perplexing to simply be freely giving guides which some people may have been making money from. Therefore we consider we have you to be grateful to for this. All the illustrations you have made, the easy blog menu, the friendships you can aid to create - it is all extraordinary, and it's letting our son in addition to the family feel that the content is brilliant, which is incredibly pressing. Many thanks for all the pieces!
supreme clothing http://www.supremes-clothing.com
Reply golden goose sneakers
9:25 AM on August 10, 2022 
I'm commenting to let you know what a great experience my friend's child found reading your site. She mastered many details, most notably what it is like to possess an ideal helping character to let certain people really easily know a number of tortuous subject matter. You really did more than my expectations. Thank you for providing these warm and friendly, safe, informative as well as cool guidance on your topic to Kate.
golden goose sneakers http://www.goldengooses.us
Reply supreme hoodie
9:24 AM on August 10, 2022 
Thanks so much for giving everyone an extremely spectacular chance to read in detail from here. It is usually very awesome and also stuffed with a good time for me personally and my office co-workers to visit your blog the equivalent of thrice every week to see the newest things you have. And of course, I am also usually satisfied with all the amazing creative ideas you serve. Selected two ideas in this posting are completely the most impressive we have all ever had.
supreme hoodie http://www.supreme-clothings.us.com
Reply kyrie irving shoes
9:24 AM on August 10, 2022 
A lot of thanks for all of your work on this site. My aunt really likes setting aside time for research and it's really simple to grasp why. Almost all hear all concerning the powerful method you produce important techniques via your web blog and even increase response from website visitors on that matter while my daughter is really studying a lot. Have fun with the rest of the new year. You're the one doing a remarkable job.
kyrie irving shoes http://www.kyrieirving-shoes.us.com
Reply sadlifebox
7:53 AM on August 10, 2022 
adidas pure boost x stella mccartney best site to buy wholesale clothing new york yankees hat 47 brand images adidas ace 15.1 cheap white and blue shoes
sadlifebox http://www.sadlifebox.com/
Reply jordan 12
7:52 AM on August 10, 2022 
I actually wanted to post a word to appreciate you for all of the nice tips and tricks you are showing here. My time consuming internet investigation has now been honored with good content to go over with my family. I would mention that we website visitors are rather endowed to be in a very good network with very many awesome people with useful tips and hints. I feel extremely lucky to have encountered your entire web site and look forward to really more entertaining moments reading here. Thanks again for everything.
jordan 12 http://www.jordan12.us.com
Reply supreme new york
8:00 PM on August 9, 2022 
I want to convey my admiration for your kindness supporting individuals who require guidance on your concern. Your special commitment to passing the message all through had been astonishingly interesting and have continuously empowered individuals just like me to attain their objectives. Your amazing warm and helpful key points means this much to me and a whole lot more to my mates. With thanks; from all of us.
supreme new york http://www.supremeclothingstore.com
Reply hermes handbags
5:05 PM on August 9, 2022 
My wife and i ended up being now peaceful when Edward managed to finish off his research via the ideas he came across through the blog. It is now and again perplexing to just possibly be freely giving tips and tricks which usually other folks could have been selling. So we see we now have the blog owner to thank for that. Most of the explanations you've made, the straightforward website menu, the friendships you can help to promote - it's mostly fantastic, and it is making our son in addition to us feel that that subject matter is brilliant, and that's really fundamental. Thank you for the whole thing!
hermes handbags http://www.hermes-handbags.us.com
Reply yeezy
3:54 PM on August 9, 2022 
I am glad for writing to make you know what a exceptional encounter my cousin's girl had going through your web site. She came to understand numerous things, which include what it is like to possess a very effective teaching spirit to let most people easily know precisely specific impossible issues. You actually did more than our own expected results. Thank you for offering those productive, trusted, edifying and also fun guidance on your topic to Ethel.
yeezy http://www.yeezy-shoes.us.org
Reply kd shoes
2:34 PM on August 9, 2022 
I truly wanted to compose a small comment to thank you for some of the remarkable suggestions you are writing here. My time consuming internet look up has at the end of the day been recognized with reputable ideas to go over with my great friends. I would point out that most of us site visitors are extremely fortunate to dwell in a very good network with very many outstanding people with very beneficial tricks. I feel very much lucky to have seen the site and look forward to plenty of more pleasurable moments reading here. Thanks a lot once again for everything.
kd shoes http://www.kevindurantshoes.us.com
Reply off white
2:34 PM on August 9, 2022 
I enjoy you because of all your hard work on this blog. Kim takes pleasure in participating in research and it is simple to grasp why. We notice all of the powerful ways you give efficient techniques on the web site and even boost participation from other people on this situation while our favorite daughter is without question being taught a lot. Take advantage of the remaining portion of the new year. You have been conducting a terrific job.
off white https://www.offwhitesoutlet.com
Reply birkin bag
2:33 PM on August 9, 2022 
I enjoy you because of all of the work on this site. My mum delights in carrying out investigation and it's simple to grasp why. My spouse and i hear all about the compelling tactic you render sensible tips and tricks by means of your website and as well invigorate participation from some others on the topic and our own simple princess is always discovering a whole lot. Have fun with the rest of the new year. You're conducting a wonderful job.
birkin bag http://www.hermesbirkins.com